Interactions and Depletions

How Vitamin B3 interacts with Anticonvulsants

Interaction Type: Depletions

Interaction Rating: Study Supported

This vitamin inhibits the breakdown of primidone and carbamazepine in the body, which could increase the risk of overdose and toxicity. This may alter the effects of these medications and possibly the dose needed for treatment. Use with caution.(1)

These drugs include primidone, carbamazepine.

References

View Abstract: Bourgeois BF, Dodson WE, Ferrendelli JA. Interactions Between Primidone, Carbamazepine, and Nicotinamide. Neurology. Oct1982;32(10):1122-26.