| The rapid production of hyaluronic acid by fibroblasts in the early
stages of wound healing may be of crucial importance as hyaluronic
acid stimulates the migration and mitosis of mesenchymal and
epithelial cells. Increased levels of hyaluronic acid, as observed
during fetal wound healing or as achieved by the topical application
of hyaluronic acid during wound dressing, are associated with brisker
healing and reduced scarring. Glucosamine availability appears to be
rate-limiting for hyaluronic acid synthesis. Thus the administration
of adequate amounts of glucosamine by mouth during the first few days
after surgery or trauma can be expected to enhance hyaluronic acid
production in the wound, promoting swifter healing and possibly
diminishing complications related to scarring.
|