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| Author: Baggio B, Gambaro G, Marzaro G |
| Date: 1991 |
| Journal: Eur J Clin Pharmacol |
| Oral administration of mixture of extractive glycosaminoglycans to a
group of renal stone formers led to a significant decrease in oxalate
self-exchange and in erythrocytes membrane protein phosphorylation
traits that are abnormal in the majority of patients with idiopathic
calcium nephrolithiasis. The action of glycosaminoglycans at the
cellular level is probably due to their modulating activity on
certain membrane protein kinases. The proven effect of the
glycosaminoglycans opens a new pharmacological approach to the
prevention of recurrent nephrolithiasis.
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