| A double-blind trial was carried out in 40 out-patients with
unilateral osteoarthrosis of the knee to compare the efficacy and
tolerance of oral treatment with 1.5 g glucosamine sulphate or 1.2 g
ibuprofen daily over a period of 8 weeks. Pain scores decreased
faster during the first 2 weeks in the ibuprofen than in the
glucosamine treatment group. Although the rate of decrease was
slower, the reduction in pain scores was continued throughout the
trial period in patients an glucosamine and the difference between
the two groups turned significantly in favour of glucosamine at Week
8. No significant differences were observed in swelling or any of the
other parameters monitored. Tolerance was satisfactory with both
treatments, with only minor complaints being reported by 2 patients
on glucosamine compared with 5 patients on ibuprofen.
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