| This study was performed to evaluate the therapeutic efficacy and
tolerability of glucosamine sulfate in patients with gonarthritis.
During the 12-month study period, the signs and symptoms of the
disease were evaluated, as well as the dosage of the urinary
pyridinoline. In this trial, we demonstrated that glucosamine sulfate
has a chondroprotective activity, which was significant after the
first 3 months of therapy. Moreover, this study showed that the side
effects due to glucosamine sulfate were mild to moderate and did not
require discontinuation of the drug.
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