| Creatine monohydrate has been shown to increase strength in studies
of young healthy subjects and in a few studies with patients.
Creatine monohydrate (10 g daily for 5 days to 5 g daily for 5 days)
was administered to patients with neuromuscular disease in a pilot
study (Study 1; n = 81), followed by a single-blinded study (Study 2;
n = 21). Body weight, handgrip, dorsiflexion, and knee extensor
strength were measured before and after treatment. Creatine
administration increased all measured indices in both studies. Short-
term creatine monohydrate increased high-intensity strength
significantly in patients with neuromuscular disease.
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